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Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
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Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
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Official URL: http://dx.doi.org/10.1016/j.drudis.2009.09.003
Abstract
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Bioinorganic chemistry, Cancer -- Treatment, Metals in medicine, Antineoplastic agents -- Development, Organometallic compounds | ||||
Journal or Publication Title: | Drug Discovery Today | ||||
Publisher: | Elsevier Ltd. | ||||
ISSN: | 1359-6446 | ||||
Official Date: | December 2009 | ||||
Dates: |
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Volume: | Vol.14 | ||||
Number: | No.23-24 | ||||
Page Range: | pp. 1089-1097 | ||||
DOI: | 10.1016/j.drudis.2009.09.003 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC), European Cooperation in the Field of Scientific and Technical Research (Organization) (COST), European Regional Development Fund (ERDF), Advantage West Midlands (AWM), Birmingham Science City |
Data sourced from Thomson Reuters' Web of Knowledge
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