The Library
Unusual DNA binding modes for metal anticancer complexes
Tools
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
PDF
WRAP_Pizarro_WRAP_PMID_19344743_Biochimie.pdf - Requires a PDF viewer. Download (952Kb) |
Official URL: http://dx.doi.org/10.1016/j.biochi.2009.03.017
Abstract
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis. New platinum drugs can be designed that have novel modes of interaction with DNA, such as the trinuclear platinum complex BBR3464. Also it is possible to design inert platinum(IV) pro-drugs which are non-toxic in the dark, but lethal when irradiated with certain wavelengths of light. This gives rise to novel DNA lesions which are not as readily repaired as those induced by cisplatin, and provides the basis for a new type of photoactivated chemotherapy. Finally, newly emerging ruthenium(II) organometallic complexes not only bind to DNA coordinatively, but also by H-bonding and hydrophobic interactions triggered by the introduction of extended arene rings into their versatile structures. Intriguingly osmium (the heavier congener of ruthenium) reacts differently with DNA but can also give rise to highly cytotoxic organometallic complexes.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Bioinorganic chemistry, Cancer -- Treatment, Metals in medicine, Antineoplastic agents -- Development, Organometallic compounds, Cisplatin -- Research, DNA-binding proteins | ||||
Journal or Publication Title: | Biochimie | ||||
Publisher: | Elsevier Masson | ||||
ISSN: | 0300-9084 | ||||
Official Date: | October 2009 | ||||
Dates: |
|
||||
Volume: | Vol.91 | ||||
Number: | No.10 | ||||
Page Range: | pp. 1198-1211 | ||||
DOI: | 10.1016/j.biochi.2009.03.017 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC), European Commission (EC), Körber-Stiftung (KS) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year