Robinson, Tristan Mark (1999) Aspects of creatine and arginine supplementation on metabolism in humans. PhD thesis, University of Warwick.

Preview

PDF WRAP_THESIS_Robinson_1999.pdf - Submitted Version - Requires a PDF viewer. Download (12Mb)

Request Changes to record.

Abstract

This thesis investigated the effects of dietary supplementation with the guanidino
compounds creatine (Cr) and arginine on metabolism in humans. Experiments
studied the influence of exercise and Cr + carbohydrate (CHO) ingestion upon
muscle glycogen and Cr accumulation, the effects of arginine ingestion upon the
fate of ingested CHO, the influence of Cr + CHO supplementation upon muscle
glycogen accumulation and endurance exercise performance, and the effects of Cr
supplementation upon various indices of health. Biochemical analysis was
performed on venous blood samples and on muscle biopsy samples from vastus
lateralis obtained from subjects during the experiments. Blood samples were
analysed for glucose, insulin and lactate concentrations and muscle samples for
adenosine triphosphate, Cr, phosphocreatine and glycogen concentrations.
Exhaustive exercise, performed prior to Cr + CHO supplementation, augmented
muscle Cr accumulation, but Cr accumulation was diminished in non-exercised
muscle. This was possibly due to a blunted CHO-stimulated insulin response
after exercise, which would diminish insulin-mediated Cr transport. Creatine +
CHO supplementation augmented glycogen resynthesis in exercised muscle to a
greater extent than CHO supplementation alone. A tendency for greater glycogen
synthesis was observed following Cr + CHO supplementation without prior
exercise, and was paralleled by a tendency for subsequent submaximal exercise to
be prolonged. Ingestion of 10 g arginine with a CHO drink was found not to have
any influence upon the fate of the ingested glucose. This was probably due to the
resulting plasma arginine concentration being insufficient to influence CHO
disposal. Finally, acute (5 day) and prolonged (8 week) Cr supplementation
produced no adverse effect upon health, as indicated by markers of
haematological, hepatological, muscle and renal function.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QP Physiology
Library of Congress Subject Headings (LCSH):	Creatine -- Physiological effect, Arginine -- Physiological effect, Metabolism
Official Date:	April 1999
Dates:	Date Event April 1999 Submitted
Institution:	University of Warwick
Theses Department:	Institute of Education
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Sewell, Dean ; Greenhaff, Paul L.
Extent:	xvi, 182, xx p.
Language:	eng

Request changes or add full text files to a record

Repository staff actions (login required)

View Item

Downloads