The Library
Age-dependent remodelling of ionotropic signalling in cortical astroglia
Tools
Lalo, Ulyana, Palygin, Oleg, North, R. Alan, Verkhratsky, Alexei and Pankratov, Yuriy (2011) Age-dependent remodelling of ionotropic signalling in cortical astroglia. Aging Cell, Vol.10 (No.3). pp. 392-402. doi:10.1111/j.1474-9726.2011.00682.x ISSN 1474-9726.
|
PDF
WRAP_Pankratov_0380313-lf-150811-ageing_cell_submission_fn_yp.pdf - Accepted Version - Requires a PDF viewer. Download (1814Kb) |
Official URL: http://dx.doi.org/10.1111/j.1474-9726.2011.00682.x
Abstract
Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial. Stimulation of neuronal afferents in mice neocortex triggers complex glial synaptic currents (GSCs) mediated by NMDA, P2X and AMPA receptors and glutamate transporters. In addition, astrocytes demonstrate spontaneous "miniature" GSCs resulting from quantal release of neurotransmitters. Here we demonstrate that maturation and ageing of the brain of mice (from 1 to 21 months) affects the density of ionotropic receptors in astrocytes and their role in GSCs generation. The AMPA receptor-mediated component is the largest in young animals and progressively declines with age. The P2X and NMDA components of GSC are smallest in young, maximal in adult (3 and 6 months old) and once more decrease in old mice, probably reflecting the remodelling of neuronal-glial circuitry. Our results demonstrate that fast synaptic transmission between neurones and astrocytes in neocortex that may be involved in information processing in neuronal-glial networks undergoes remodelling during brain maturation and ageing.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
||||
Library of Congress Subject Headings (LCSH): | Astrocytes, Cerebral cortex, Brain -- Aging, Neural transmission | ||||
Journal or Publication Title: | Aging Cell | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1474-9726 | ||||
Official Date: | June 2011 | ||||
Dates: |
|
||||
Volume: | Vol.10 | ||||
Number: | No.3 | ||||
Page Range: | pp. 392-402 | ||||
DOI: | 10.1111/j.1474-9726.2011.00682.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Grantová agentura České republiky [Grant Agency of the Czech Republic] (GACR) | ||||
Grant number: | BB/F021445 (BBSRC), GACR 305/08/1381 (GACR), GACR 305/08/1384 (GACR) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year