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The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
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(2011) The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis. Annals of the Rheumatic Diseases, Vol.70 (No.9). pp. 1556-1561. doi:10.1136/ard.2010.148122 ISSN 0003-4967.
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Official URL: http://dx.doi.org/10.1136/ard.2010.148122
Abstract
Objective To assess if a coding variant in the gene
encoding transient receptor potential cation channel,
subfamily V, member 1 ( TRPV1 ) is associated with
genetic risk of painful knee osteoarthritis (OA).
Methods The Ile585Val TRPV1 variant encoded by
rs8065080 was genotyped in 3270 cases of symptomatic
knee OA, 1098 cases of asymptomatic knee OA and
3852 controls from seven cohorts from the UK, the USA
and Australia. The genetic association between the
low-pain genotype Ile–Ile and risk of symptomatic and
asymptomatic knee OA was assessed.
Results The TRPV1 585 Ile–Ile genotype, reported to
be associated with lower thermal pain sensitivity, was
associated with a lower risk of symptomatic knee OA
in a comparison of symptomatic cases with healthy
controls, with an odds ratio (OR) of 0.75 (95% CI 0.64
to 0.88; p=0.00039 by meta-analysis) after adjustment
for age, sex and body mass index. No difference was
seen between asymptomatic OA cases and controls
(OR=1.02, 95% CI 0.82 to 1.27 p=0.86) but the Ile–Ile
genotype was associated with lower risk of symptomatic
versus asymptomatic knee OA adjusting for covariates
and radiographic severity (OR=0.73, 95% CI 0.57 to 0.94
p=0.0136). TRPV1 expression in articular cartilage was
increased by infl ammatory cytokines (tumour necrosis
factor α and interleukin 1). However, there were no
differences in TRPV1 expression in healthy and arthritic
synovial tissue.
Conclusions A genotype involved in lower peripheral
pain sensitivity is signifi cantly associated with a
decreased risk of painful knee OA. This indicates a role for
the pro-nociceptive gene TRPV1 in genetic susceptibility
to symptomatic knee OA, which may also be infl uenced
by a role for this molecule in cartilage function.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Osteoarthritis -- Genetic aspects, Knee -- Diseases -- Genetic aspects | ||||
Journal or Publication Title: | Annals of the Rheumatic Diseases | ||||
Publisher: | BMJ Group | ||||
ISSN: | 0003-4967 | ||||
Official Date: | 25 May 2011 | ||||
Dates: |
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Volume: | Vol.70 | ||||
Number: | No.9 | ||||
Page Range: | pp. 1556-1561 | ||||
DOI: | 10.1136/ard.2010.148122 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Funder: | Seventh Framework Programme (European Commission) (FP7), AstraZeneca (Firm), Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), National Institute for Health Research (Great Britain) (NIHR), Arthritis Research Campaign (Organization), National Health and Medical Research Council (Australia) (NHMRC), Arthritis Foundation of Australia, Tasmanian Community Fund, University of Tasmania | ||||
Grant number: | 200800 TREAT-OA (FP7) |
Data sourced from Thomson Reuters' Web of Knowledge
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