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Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire
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Dakin, Helen, Petrou, Stavros, Haggard, Mark, Benge, Sarah and Williamson, I. (Ian), Dr. (2010) Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire. Quality of Life Research, Vol.19 (No.1). pp. 65-80. doi:10.1007/s11136-009-9558-z ISSN 0962-9343.
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Official URL: http://dx.doi.org/10.1007/s11136-009-9558-z
Abstract
Purpose
To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.
Methods
A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.
Results
OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.
Conclusion
Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RF Otorhinolaryngology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Otitis media with effusion in children -- Treatment, Quality of life, Health surveys, Health status indicators | ||||
| Journal or Publication Title: | Quality of Life Research | ||||
| Publisher: | Springer Netherlands | ||||
| ISSN: | 0962-9343 | ||||
| Official Date: | February 2010 | ||||
| Dates: |
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| Volume: | Vol.19 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 65-80 | ||||
| DOI: | 10.1007/s11136-009-9558-z | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | NIHR Health Technology Assessment Programme (Great Britain) (NIHR HTA) |
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