Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, Bruno M. P. M. and Pinto, Alberto A. (2011) A transcritical bifurcation in an immune response model. Journal of Difference Equations and Applications, Vol.17 (No.7). pp. 1101-1106. doi:10.1080/10236190903095291 ISSN 1023-6198.

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Abstract

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We find a transcritical bifurcation that might explain two alternative scenarios: in one case the appearance of autoimmune responses and in another the suppression of the immune response.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Library of Congress Subject Headings (LCSH):	T cells, Immune response -- Mathematical models, Bifurcation theory, T cells -- Receptors, Immune response -- Regulation
Journal or Publication Title:	Journal of Difference Equations and Applications
Publisher:	Taylor & Francis Inc.
ISSN:	1023-6198
Official Date:	2011
Dates:	Date Event 2011 Published
Volume:	Vol.17
Number:	No.7
Page Range:	pp. 1101-1106
DOI:	10.1080/10236190903095291
Status:	Peer Reviewed
Publication Status:	Published
Funder:	Fundação para a Ciência e a Tecnologia (FCT), Portugal. Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Fundação Calouste Gulbenkian (FCG), Universidade do Minho (UdM), Universidade do Porto (UP)

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