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Organometallic cis-Dichlorido ruthenium(II) ammine complexes
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Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
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Official URL: http://dx.doi.org/10.1002/ejic.201100250
Abstract
Bifunctional neutral half-sandwich RuII complexes of the type [(η6-arene)Ru(NH3)Cl2] where arene is p-cym (1) or bip (2) were synthesised by the reaction of N,N-dimethylbenzylamine (dmba), NH4PF6 and the corresponding RuII arene dimer, and were fully characterised. X-ray crystallographic studies of [(η6-p-cym)Ru(NH3)Cl2]·{(dmba–H)(PF6)} (1a) and [(η6-bip)Ru(NH3)Cl2] (2) show extensive H-bond interactions in the solid state, mainly involving the NH3 and the Cl ligands, as well as weak aromatic stacking interactions. The half-lives for the sequential hydrolysis of 1 and 2 determined by UV/Vis spectroscopy at 310 K ranged from a few minutes for the first aquation to ca. 45 min for the second aquation; the diaqua adducts were the predominant species at equilibrium. Arene loss during the aquation of complex 2 was observed. Upon hydrolysis, both complexes readily formed mono- and di-9-ethylguanine (9-EtG) adducts in aqueous solution at 310 K. The reaction reached equilibrium after ca. 1.8 h in the case of complex 1 and was slower but more complete for complex 2 (before the onset of arene loss at ca. 2.7 h). Complexes 1 and 2 were not cytotoxic towards A2780 human ovarian cancer cells up to the maximum concentration tested (100 μM).
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Ruthenium, Antineoplastic agents, Ligands (Biochemistry), Cell-mediated cytotoxicity, Organometallic chemistry, Complex compounds, Cancer cells | ||||
| Journal or Publication Title: | European Journal of Inorganic Chemistry | ||||
| Publisher: | Wiley-VCH Verlag GMBH | ||||
| ISSN: | 1434-1948 | ||||
| Official Date: | July 2011 | ||||
| Dates: |
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| Volume: | Volume 2011 | ||||
| Number: | Number 21 | ||||
| Page Range: | pp. 3257-3264 | ||||
| DOI: | 10.1002/ejic.201100250 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 18 December 2015 | ||||
| Date of first compliant Open Access: | 18 December 2015 | ||||
| Funder: | University of Warwick Postgraduate Research Scholarship, Overseas Research Students Awards Scheme (ORSAS), Consejo Nacional de Ciencia y Tecnología (Mexico) [Mexican Council for Science and Technology] (CONACYT) , European Regional Development Fund (ERDF), Advantage West Midlands (AWM), Science City Research Alliance, European Research Council (ERC) |
Data sourced from Thomson Reuters' Web of Knowledge
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