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Quantitative analysis of regulatory flexibility under changing environmental conditions
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Edwards, Kieron D., Akman, Ozgur E., Knox, Kirsten, Lumsden, P. J., Thomson, Adrian W., Brown, Paul E., Pokhilko, Alexandra, Kozma-Bognar, Laszlo, Nagy, Ferenc, Rand, D. A. and Millar, A. J. (2010) Quantitative analysis of regulatory flexibility under changing environmental conditions. Molecular Systems Biology, Vol.6 (No.424). doi:10.1038/msb.2010.81 ISSN 1744-4292.
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Official URL: http://dx.doi.org/10.1038/msb.2010.81
Abstract
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecular rhythms to track multiple phases of the external cycle. Clear dawn- and dusk-tracking rhythms illustrate the flexibility of timing in Ipomoea nil. Molecular clock components in Arabidopsis thaliana showed complex, photoperiod-dependent regulation, which was analysed by comparison with three contrasting models. A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening-expressed clock genes showed photoperiod-dependent dusk sensitivity, as predicted by the three-loop model, whereas the one- and two-loop models tracked dawn and dusk, respectively. Output genes for starch degradation achieved dusk-tracking expression through light regulation, rather than a dusk-tracking rhythm. Model analysis predicted which biochemical processes could be manipulated to extend dusk tracking. Our results reveal how an operating principle of biological regulators applies specifically to the plant circadian clock.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QK Botany | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
Library of Congress Subject Headings (LCSH): | Circadian rhythms, Arabidopsis thaliana, Plant genetic regulation, Plant photoperiodism | ||||
Journal or Publication Title: | Molecular Systems Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1744-4292 | ||||
Official Date: | 2 November 2010 | ||||
Dates: |
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Volume: | Vol.6 | ||||
Number: | No.424 | ||||
Number of Pages: | 11 | ||||
DOI: | 10.1038/msb.2010.81 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Sixth Framework Programme (European Commission) (FP6) | ||||
Grant number: | G19886 (BBSRC), E015263 (BBSRC), EUCLOCK (FP6), D019621 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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