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Labor and inflammation increase the expression of oxytocin receptor in human amnion
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Terzidou, Vasso, Blanks, Andrew M., Kim, Sung Hye, Thornton, Steven and Bennett, Phillip R. (2011) Labor and inflammation increase the expression of oxytocin receptor in human amnion. Biology of Reproduction, Volume 84 (Number 3). pp. 546-552. doi:10.1095/biolreprod.110.086785 ISSN 0006-3363.
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Official URL: http://dx.doi.org/10.1095/biolreprod.110.086785
Abstract
The oxytocin/oxytocin receptor (OXT/OXTR) system plays an important role in the regulation of parturition. The amnion is a major source of prostaglandins and inflammatory cytokine synthesis, which increase both before and during labor. Amnion is a noncontractile tissue; therefore, the role played by OXT/OXTR in this tissue will be fundamentally different from the role played in myometrial contractions. In the present study, we demonstrate increased OXTR mRNA and protein concentrations in human amnion epithelial cells associated with the onset of labor. We show that incubation of primary human amnion epithelial cells with IL1B results in a rapid, transient up-regulation of OXTR mRNA expression, which peaks in prelabor samples after 6 h. Incubation of prelabor amnion epithelial cells with OXT results in a marked increase of prostaglandin E(2) synthesis, and we demonstrate that OXT activates the extracellular signal-regulated protein kinase signal transduction pathway to stimulate up-regulation of cyclo-oxygenase 2 in human amnion epithelial cells. The increased ability of human amnion to produce prostaglandins in response to OXT treatment suggests a complementary role for the OXT/OXTR system in the activation of human amnion and the onset of labor.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Oxytocin -- Receptors, Amnion, Inflammation, Prostaglandins, Parturition | ||||
| Journal or Publication Title: | Biology of Reproduction | ||||
| Publisher: | Society for the Study of Reproduction | ||||
| ISSN: | 0006-3363 | ||||
| Official Date: | March 2011 | ||||
| Dates: |
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| Volume: | Volume 84 | ||||
| Number: | Number 3 | ||||
| Page Range: | pp. 546-552 | ||||
| DOI: | 10.1095/biolreprod.110.086785 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Action Medical Research (AMR), National Institute for Health Research (Great Britain) (NIHR) | ||||
| Grant number: | SP4454 (AMR), DSRR_NG0122/2009 (NIHR) |
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