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Tricyclic antidepressants and the incidence of certain cancers : a study using the GPRD
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Walker, A. J., Card, T., Bates, T. E. and Muir, Kenneth (Kenneth R.) (2011) Tricyclic antidepressants and the incidence of certain cancers : a study using the GPRD. British Journal of Cancer, Volume 104 (Number 1). pp. 193-197. doi:10.1038/sj.bjc.6605996 ISSN 0007-0920.
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Official URL: http://dx.doi.org/10.1038/sj.bjc.6605996
Abstract
BACKGROUND: Several studies suggest links between cancer and tricyclic antidepressant use.
METHODS: A case-control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, colorectal, lung and prostate cancers. Conditional logistic regression adjusted for age, gender, general practice, depression, smoking, body mass index, alcohol use and non-steroidal anti-inflammatory drug use.
RESULTS: A total of 31 953 cancers were identified, each matched with up to two controls. We found a statistically significant reduction in tricyclic prescriptions compared with controls in glioma (odds ratio (OR) = 0.59, 95% confidence interval (CI) = 0.42-0.81) and colorectal cancer patients (OR = 0.84, CI = 0.75-0.94). These effects were dose-dependent (P-values for trend, glioma = 0.0005, colorectal = 0.001) and time-dependant (P-values for trend glioma = 0.0005, colorectal = 0.0086). The effects were cancer-type specific, with lung, breast and prostate cancers largely unaffected by antidepressant use.
CONCLUSION: The biologically plausible, specific and dose-and time-dependant inverse association that we have found suggests that tricyclics may have potential for prevention of both colorectal cancer and glioma. British Journal of Cancer (2011) 104, 193-197. doi: 10.1038/sj.bjc.6605996 www.bjcancer.com Published online 16 November 2010 (C) 2011 Cancer Research UK
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Antidepressants, Gliomas, Colon (Anatomy) -- Cancer -- Treatment, Rectum -- Cancer -- Treatment, General Practice Research Database | ||||
Journal or Publication Title: | British Journal of Cancer | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 0007-0920 | ||||
Official Date: | 4 January 2011 | ||||
Dates: |
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Volume: | Volume 104 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 193-197 | ||||
DOI: | 10.1038/sj.bjc.6605996 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Medical Research Council (Great Britain) (MRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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