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Phosphoprotein enriched in diabetes gene product (Ped/pea-15) is increased in omental adipose tissue of women with the polycystic ovary syndrome : ex vivo regulation of ped/pea-15 by glucose, insulin and metformin
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Tan, B. K., Chen, J., Adya, Raghu and Randeva, Harpal S. (2011) Phosphoprotein enriched in diabetes gene product (Ped/pea-15) is increased in omental adipose tissue of women with the polycystic ovary syndrome : ex vivo regulation of ped/pea-15 by glucose, insulin and metformin. Diabetes, Obesity and Metabolism, Vol.13 (No.2). pp. 181-184. doi:10.1111/j.1463-1326.2010.01329.x ISSN 1462-8902.
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Official URL: http://dx.doi.org/10.1111/j.1463-1326.2010.01329.x
Abstract
Polycystic ovary syndrome (PCOS), the commonest endocrine disorder in women, is characterized by an altered steroid milieu and is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Phosphoprotein enriched in diabetes gene product (Ped/pea-15) regulates glucose metabolism and is increased in T2DM. Our novel data indicate that Ped/pea-15 mRNA expression and protein levels are significantly increased in omental adipose tissue (AT) from PCOS women compared to matched controls (p < 0.01); Ped/pea-15 levels in subcutaneous AT were not significantly different. Furthermore, Ped/pea-15 mRNA expression and protein levels were higher in omental compared to subcutaneous AT in PCOS subjects (p < 0.01); however, in control subjects, this was not significant. Glucose was predictive of omental AT Ped/pea-15 mRNA expression (p = 0.045). Importantly, glucose and insulin increased whereas metformin significantly decreased Ped/pea-15 levels in human omental AT explants. Our findings should serve to promote further research on Ped/pea-15 biology.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Diabetes, Obesity and Metabolism | ||||
| Publisher: | Blackwell | ||||
| ISSN: | 1462-8902 | ||||
| Official Date: | February 2011 | ||||
| Dates: |
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| Volume: | Vol.13 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 181-184 | ||||
| DOI: | 10.1111/j.1463-1326.2010.01329.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | General Charities of the City of Coventry |
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