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Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism
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Chamberlain, Kerry L., Marshall, Richard S., Jolliffe, Nicholas A., Frigerio, Lorenzo, Ceriotti, Aldo, Lord, Mike and Roberts, L. M. (Lynne M.) (2008) Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism. Journal of Biological Chemistry, Vol.283 (No.48). pp. 33276-33286. doi:10.1074/jbc.M805222200 ISSN 0021-9258.
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Official URL: http://dx.doi.org/10.1074/jbc.M805222200
Abstract
The B chain of ricin was expressed and delivered to the endoplasmic
reticulum of tobacco protoplasts where it disappeared
with time in a manner consistent with degradation. This turnover
did not occur in the vacuoles or upon secretion. Indeed,
several lines of evidence indicate that, in contrast to the turnover
of endoplasmic reticulum-targeted ricin A chain in the
cytosol, the bulk of expressed ricin B chain was degraded in the
secretory pathway.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Ricin, Tobacco -- Physiology, Endoplasmic reticulum | ||||
Journal or Publication Title: | Journal of Biological Chemistry | ||||
Publisher: | American Society for Biochemistry and Molecular Biology, Inc. | ||||
ISSN: | 0021-9258 | ||||
Official Date: | 28 November 2008 | ||||
Dates: |
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Volume: | Vol.283 | ||||
Number: | No.48 | ||||
Page Range: | pp. 33276-33286 | ||||
DOI: | 10.1074/jbc.M805222200 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust (London, England) | ||||
Grant number: | 080566/Z/06/Z (Wellcome) |
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