Ting, Stephen M. , Koganti, Sudheer, Higgins, Rob, Imray, C. (Chris), Aldridge, Nicolas, Bland, Rosemary, Zehnder, Daniel and Banerjee, Prithwish (2011) Left ventricular diastolic dysfunction is associated with increased vascular resistance and reduced VO2max in patients awaiting kidney transplantation. Circulation, Vol.124 . Article no. A9270. ISSN 0009-7322.

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Abstract

Hypothesis: Chronic heart failure (CHF) is a major contributor to high mortality in chronic kidney disease (CKD) patients. We hypothesize that LV diastolic stiffness, in part caused by loss of large artery elasticity in CKD, promotes reduction in cardiovascular reserve.

Methods: 68 CKD patients (age, 46 ± 13 years; male, 61%) waitlisted for kidney transplantation were prospectively recruited in 2010. TD echocardiography, arterial pulse wave velocity (PWV) and symptom-limited cardiopulmonary exercise testing were performed to determine the relationship between LV diastolic function, arterial stiffness and cardiovascular reserve. Patients were evaluated and categorised into quartile groups according to the level of maximal exercise oxygen capacity (VO2max).

Results: Reduced VO2max was significantly associated with higher E/E (p= 0.002). E/E was calculated using the averaged of septal and lateral mitral annular lengthening velocities. A high E/E was also associated with a worse anaerobic threshold (AT) (p<0.001). These patients (with low VO2max and high E/E) also demonstrated a significantly greater aortic stiffness (p= 0.026). VO2max was inversely correlated with both E/E (r= -0.413, p= 0.001) and PWV (r= -0.355, p= 0.003). Distribution of gender and history of coronary artery disease were no different between the groups.

Conclusions: Evidence for diastolic dysfunction with increased LV filling pressure and diastolic stiffness by the measure of E/E was strongly associated with poor functional cardiovascular reserve. The importance of ventriculo-arterial coupling in the complex mechanism of CKD mediated CHF is evidenced by the significant association between high E/E and increased aortic stiffness.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Circulation
Publisher:	American Heart Association
ISSN:	0009-7322
Official Date:	2011
Dates:	Date Event 2011 Published
Volume:	Vol.124
Page Range:	Article no. A9270
Status:	Peer Reviewed
Publication Status:	Published

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