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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
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(2009) Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, Vol.41 (No.10). pp. 1116-1121. doi:10.1038/ng.450 ISSN 1061-4036.
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Official URL: http://dx.doi.org/10.1038/ng.450
Abstract
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33).
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1061-4036 | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.41 | ||||
Number: | No.10 | ||||
Page Range: | pp. 1116-1121 | ||||
DOI: | 10.1038/ng.450 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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