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Diagnostic radiation procedures and risk of prostate cancer
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Myles, P., Evans, S., Lophatananon, Artitaya, Dimitropoulou, Polyxeni, Easton, Douglas F., Key, Tim J., Pocock, R., Dearnaley, David P., Guy, M., Edwards, S., O'Brien, L., Gehr-Swain, B., Hall, A., Wilkinson, Rosemary A., Eeles, Rosalind A. and Muir, Kenneth (2008) Diagnostic radiation procedures and risk of prostate cancer. British Journal of Cancer, Vol.98 (No.11). pp. 1852-1856. doi:10.1038/sj.bjc.6604370 ISSN 0007-0920.
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Official URL: http://dx.doi.org/10.1038/sj.bjc.6604370
Abstract
Exposure to ionising radiation is an established risk factor for many cancers. We conducted a case–control study to investigate whether exposure to low dose ionisation radiation from diagnostic x-ray procedures could be established as a risk factor for prostate cancer. In all 431 young-onset prostate cancer cases and 409 controls frequency matched by age were included. Exposures to barium meal, barium enema, hip x-rays, leg x-rays and intravenous pyelogram (IVP) were considered. Exposures to barium enema (adjusted odds ratio (OR) 2.06, 95% confidence interval (CI) 1.01–4.20) and hip x-rays (adjusted OR 2.23, 95% CI 1.42–3.49) at least 5 years before diagnosis were significantly associated with increased prostate cancer. For those with a family history of cancer, exposures to hip x-rays dating 10 or 20 years before diagnosis were associated with a significantly increased risk of prostate cancer: adjusted OR 5.01, 95% CI 1.64–15.31 and adjusted OR 14.23, 95% CI 1.83–110.74, respectively. Our findings show that exposure of the prostate gland to diagnostic radiological procedures may be associated with increased cancer risk. This effect seems to be modified by a positive family history of cancer suggesting that genetic factors may play a role in this risk association.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | British Journal of Cancer | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 0007-0920 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.98 | ||||
Number: | No.11 | ||||
Page Range: | pp. 1852-1856 | ||||
DOI: | 10.1038/sj.bjc.6604370 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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