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How to halve ploidy : lessons from budding yeast meiosis
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Kerr, Gary W., Sarkar, Sourav and Arumugam, Prakash (2012) How to halve ploidy : lessons from budding yeast meiosis. Cellular and Molecular Life Sciences, Volume 69 (Number 18). pp. 3037-3051. doi:10.1007/s00018-012-0974-9
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WRAP_Arumugam_0672749-lf-230412-cmls-d-12-000831.pdf - Accepted Version Download (1240Kb) |
Official URL: http://dx.doi.org/10.1007/s00018-012-0974-9
Abstract
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | Meiosis, Gametogenesis, Saccharomyces cerevisiae | ||||
| Journal or Publication Title: | Cellular and Molecular Life Sciences | ||||
| Publisher: | Springer | ||||
| ISSN: | 1420-682X | ||||
| Official Date: | 5 April 2012 | ||||
| Dates: |
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| Volume: | Volume 69 | ||||
| Number: | Number 18 | ||||
| Page Range: | pp. 3037-3051 | ||||
| DOI: | 10.1007/s00018-012-0974-9 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | BB/G00353X/1 (BBSRC) |
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