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Diurnal variation and effect of insulin on circulating high molecular weight (HMW) adiponectin and NF-κB activity in human endothelial cells
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Tan, Bee K., Adya, Raghu, Lewandowski, Krzysztof C., O'Hare, J. Paul and Randeva, Harpal S. (2011) Diurnal variation and effect of insulin on circulating high molecular weight (HMW) adiponectin and NF-κB activity in human endothelial cells. Atherosclerosis, Vol.214 (No.1). pp. 174-177. doi:10.1016/j.atherosclerosis.2010.10.013 ISSN 0021-9150.
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Official URL: http://dx.doi.org/10.1016/j.atherosclerosis.2010.1...
Abstract
Objective
To study the diurnal variation and the effect of insulin on adiponectin multimers and nuclear factor-kappaB (NF-κB) activity in human endothelial cells.
Methods and results
We utilized a prolonged insulin–glucose infusion in six healthy human subjects. HMW and total adiponectin levels were higher in the morning and lower at night; NF-κB activities in serum treated human microvascular endothelial cells (HMEC-1) cells were lower in the morning and higher at night. Hyperinsulinemic induction significantly decreased HMW and total adiponectin levels but increased NF-κB activity in serum treated HMEC-1 cells (P < 0.05, P < 0.01). There were no significant changes to MMW and LMW adiponectin levels (P > 0.05).
Conclusion
Circadian rhythm of HMW adiponectin and NF-κB activity are altered by hyperinsulinemia providing novel insights adiponectin and NF-κB biology, which may be pertinent to insulin resistant states, e.g. obesity and type 2 diabetes mellitus.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Atherosclerosis | ||||
| Publisher: | Elsevier Ireland Ltd. | ||||
| ISSN: | 0021-9150 | ||||
| Official Date: | January 2011 | ||||
| Dates: |
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| Volume: | Vol.214 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 174-177 | ||||
| DOI: | 10.1016/j.atherosclerosis.2010.10.013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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