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Quantitative asymmetric reaction kinetics
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Rushworth, Philip John (2011) Quantitative asymmetric reaction kinetics. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b2565547~S1
Abstract
The comparison of catalysts for producing chiral materials is of vital importance
in the improvement of reaction scope and efficacy. Here we describe a new
method of analysing the kinetics of the stereodetermining steps in asymmetric
reactions by performing ligand/catalyst competition experiments against an
internal standard and measuring the enantiomeric excess obtained at a variety of
ratios of ligand/catalyst to internal standard. From these enantiomeric excess
measurements, we can establish the relative rate of reaction between the
ligand/catalyst systems and the internal standard, allowing us to make indirect
comparisons of the rates at which the ligands/catalysts perform the reaction.
Here we take this method and apply it to three common synthetic procedures: the
Sharpless asymmetric dihydroxylation, the asymmetric Michael addition of
malonates to nitroalkenes and palladium catalysed asymmetric allylation
reaction.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Enantioselective catalysis, Chemical kinetics | ||||
Official Date: | October 2011 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Department of Chemistry | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Fox, David | ||||
Sponsors: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Extent: | x, 218 leaves : ill., charts | ||||
Language: | eng |
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