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Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1
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Kajihara, T., Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J. and Ishihara, Osamu (2009) Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Medical Molecular Morphology, Vol.42 (No.4). pp. 216-221. doi:10.1007/s00795-009-0466-7 ISSN 1860-1480.
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Official URL: http://dx.doi.org/10.1007/s00795-009-0466-7
Abstract
It is well established that hyperinsulinemia, resulting from insulin resistance, plays a role in the pathophysiology of polycystic ovary syndrome (PCOS). The aim of this study was to investigate if ovarian follicular development and atresia are impaired in obese hyperinsulinemic (fa/fa) Zucker rats. To gain insight into the molecular mechanism of follicular atresia, we also examined the expression and localization of forkhead transcription factor FOXO1, a major regulator of cell fate decisions such as differentiation, cell-cycle arrest, and cell death. Serum insulin but not gonadotropin levels were significantly higher in obese (fa/fa) rats when compared to lean controls. Total ovarian follicle number and the percentage of atretic follicles were also significantly increased in obese (fa/fa) rats. Follicle atresia was associated with nuclear accumulation of FOXO1 transcription factor in TUNEL-positive granulosa cells. These results suggest a role for FOXO1 in granulosa cell apoptosis and increased ovarian follicle atresia associated with hyperinsulinemia.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Apoptosis, Ovarian atresia, Zucker rats -- Physiology, Polycystic ovary syndrome -- Etiology -- Research, Transcription factors | ||||
| Journal or Publication Title: | Medical Molecular Morphology | ||||
| Publisher: | Springer Japan KK | ||||
| ISSN: | 1860-1480 | ||||
| Official Date: | December 2009 | ||||
| Dates: |
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| Volume: | Vol.42 | ||||
| Number: | No.4 | ||||
| Page Range: | pp. 216-221 | ||||
| DOI: | 10.1007/s00795-009-0466-7 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | Japan. Monbu Kagakushō [Japan. Ministry of Education, Culture, Sports, Science and Technology] (MEXT) |
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