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Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation : Whitehall II study
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Tabák, A. G., Brunner, E. J., Miller, Michelle A., Karanam, S., McTernan, P. G. (Philip G.), Cappuccio, Francesco and Witte, D. R. (2009) Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation : Whitehall II study. Hormone and Metabolic Research, Vol.41 (No.8). pp. 626-629. doi:10.1055/s-0029-1216359 ISSN 0018-5043.
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Official URL: http://dx.doi.org/10.1055/s-0029-1216359
Abstract
Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n=140) of the Whitehall II Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5±3.0 years). Adiponectin levels were lower among cases (9.3 μg/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 μg/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Hormone and Metabolic Research | ||||
| Publisher: | Georg Thieme Verlag | ||||
| ISSN: | 0018-5043 | ||||
| Official Date: | August 2009 | ||||
| Dates: |
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| Volume: | Vol.41 | ||||
| Number: | No.8 | ||||
| Page Range: | pp. 626-629 | ||||
| DOI: | 10.1055/s-0029-1216359 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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