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Omentin : a novel link between inflammation, diabesity, and cardiovascular disease
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Tan, Bee K., Adya, Raghu and Randeva, Harpal S. (2010) Omentin : a novel link between inflammation, diabesity, and cardiovascular disease. Trends in Cardiovascular Medicine, Vol.20 (No.5). pp. 143-148. doi:10.1016/j.tcm.2010.12.002 ISSN 1050-1738.
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Official URL: http://dx.doi.org/10.1016/j.tcm.2010.12.002
Abstract
Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue–secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein–induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Trends in Cardiovascular Medicine | ||||
| Publisher: | Elsevier Inc. | ||||
| ISSN: | 1050-1738 | ||||
| Official Date: | July 2010 | ||||
| Dates: |
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| Volume: | Vol.20 | ||||
| Number: | No.5 | ||||
| Page Range: | pp. 143-148 | ||||
| DOI: | 10.1016/j.tcm.2010.12.002 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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