Thornalley, Paul J. (2011) Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease. Drug Metabolism and Drug Interactions, Vol.23 (No.1-2). pp. 125-150. doi:10.1515/DMDI.2008.23.1-2.125 ISSN 0792-5077.

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Abstract

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these alpha-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Drug Metabolism and Drug Interactions
Publisher:	Walter de Gruyter GmbH & Co. KG
ISSN:	0792-5077
Official Date:	May 2011
Dates:	Date Event May 2011 Published
Volume:	Vol.23
Number:	No.1-2
Page Range:	pp. 125-150
DOI:	10.1515/DMDI.2008.23.1-2.125
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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