The Library
The use of plants for the production of therapeutic human peptides
Tools
Lico, Chiara, Santi, Luca, Twyman, Richard M., Pezzotti, Mario and Avesani, Linda (2012) The use of plants for the production of therapeutic human peptides. Plant Cell Reports, Vol.31 (No.3). pp. 439-451. doi:10.1007/s00299-011-1215-7 ISSN 0721-7714.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1007/s00299-011-1215-7
Abstract
Peptides have unique properties that make them useful drug candidates for diverse indications, including allergy, infectious disease and cancer. Some peptides are intrinsically bioactive, while others can be used to induce precise immune responses by defining a minimal immunogenic region. The limitations of peptides, such as metabolic instability, short half-life and low immunogenicity, can be addressed by strategies such as multimerization or fusion to carriers, to improve their pharmacological properties. The remaining major drawback is the cost of production using conventional chemical synthesis, which is also difficult to scale-up. Over the last 15 years, plants have been shown to produce bioactive and immunogenic peptides economically and with the potential for large-scale synthesis. The production of peptides in plants is usually achieved by the genetic fusion of the corresponding nucleotide sequence to that of a carrier protein, followed by stable nuclear or plastid transformation or transient expression using bacterial or viral vectors. Chimeric plant viruses or virus-like particles can also be used to display peptide antigens, allowing the production of polyvalent vaccine candidates. Here we review progress in the field of plant-derived peptides over the last 5 years, addressing new challenges for diverse pathologies.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > Q Science (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
||||
Journal or Publication Title: | Plant Cell Reports | ||||
Publisher: | Springer | ||||
ISSN: | 0721-7714 | ||||
Official Date: | March 2012 | ||||
Dates: |
|
||||
Volume: | Vol.31 | ||||
Number: | No.3 | ||||
Page Range: | pp. 439-451 | ||||
DOI: | 10.1007/s00299-011-1215-7 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |