Harte, James M., Rønne, Filip Munch and Dau, Torsten (2010) Modeling human auditory evoked brainstem responses based on nonlinear cochlear processing. In: 20th International Congress on Acoustics (ICA 2010), Sydney, New South Wales, Australia, Aug 23-27, 2010. Published in: Proceedings of the 20th International Congress on Acoustics pp. 1-9.

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Abstract

The aim of this study was to accurately simulate auditory evoked potentials (AEPs) from various classical stimuli such as clicks, chirps and tones, often used in research and clinical diagnostics. In an approach similar to Dau (2003), a model was developed for the generation of auditory brainstem responses (ABR) to transient sounds and frequency following responses (FFR) to tones. The model includes important cochlear processing stages (Zilany and Bruce, 2006) such as basilar-membrane tuning and compression, inner hair-cell (IHC) transduction, and IHC auditory-nerve (AN) synapse adaptation. To generate AEPs recorded at remote locations, a convolution was made on an elementary unit waveform (obtained empirically) with the instantaneous discharge rate function for the corresponding AN unit. AEPs to click-trains as well as to tone pulses at various frequencies were both modelled and recorded at different stimulation levels and repetition rates. The observed nonlinearities in the recorded potential patterns with respect to ABR wave latencies and amplitudes could be largely accounted for by level-dependent BM processing as well as effects of short-term neural adaptation. The present study provides further evidence for the importance of cochlear tuning and AN adaptation on AEP patterns and provides a useful basis for the study of more complex stimuli including speech.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > RF Otorhinolaryngology T Technology > TA Engineering (General). Civil engineering (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Proceedings of the 20th International Congress on Acoustics
Publisher:	International Commission for Acoustics
Official Date:	August 2010
Dates:	Date Event August 2010 Published
Page Range:	pp. 1-9
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Conference Paper Type:	Paper
Title of Event:	20th International Congress on Acoustics (ICA 2010)
Type of Event:	Other
Location of Event:	Sydney, New South Wales, Australia
Date(s) of Event:	Aug 23-27, 2010

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