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T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology
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Clokie, Martha R. J., Millard, Andrew D. and Mann, Nicholas H. (2010) T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology. Virology Journal, Volume 7 . Article number 291. doi:10.1186/1743-422X-7-291
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Official URL: http://dx.doi.org/10.1186/1743-422X-7-291
Abstract
From genomic sequencing it has become apparent that the marine cyanomyoviruses capable of infecting strains of unicellular cyanobacteria assigned to the genera Synechococcus and Prochlorococcus are not only morphologically similar to T4, but are also genetically related, typically sharing some 40-48 genes. The large majority of these common genes are the same in all marine cyanomyoviruses so far characterized. Given the fundamental physiological differences between marine unicellular cyanobacteria and heterotrophic hosts of T4-like phages it is not surprising that the study of cyanomyoviruses has revealed novel and fascinating facets of the phage-host relationship. One of the most interesting features of the marine cyanomyoviruses is their possession of a number of genes that are clearly of host origin such as those involved in photosynthesis, like the psbA gene that encodes a core component of the photosystem II reaction centre. Other host-derived genes encode enzymes involved in carbon metabolism, phosphate acquisition and ppGpp metabolism. The impact of these host-derived genes on phage fitness has still largely to be assessed and represents one of the most important topics in the study of this group of T4-like phages in the laboratory. However, these phages are also of considerable environmental significance by virtue of their impact on key contributors to oceanic primary production and the true extent and nature of this impact has still to be accurately assessed.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cyanobacteria , Cyanobacteria -- Genetics, Genomics , Marine ecology | ||||
| Journal or Publication Title: | Virology Journal | ||||
| Publisher: | BioMed Central Ltd. | ||||
| ISSN: | 1743-422X | ||||
| Official Date: | 28 October 2010 | ||||
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| Volume: | Volume 7 | ||||
| Number of Pages: | 19 | ||||
| Page Range: | Article number 291 | ||||
| DOI: | 10.1186/1743-422X-7-291 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
Data sourced from Thomson Reuters' Web of Knowledge
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