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Regulation of metabolism, aging and lifespan by microRNAs
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Zhang, Junlong (2008) Regulation of metabolism, aging and lifespan by microRNAs. In: Lyland, Roger T. and Browning, Irving B., (eds.) RNA interference research progress. New York: Nova Biomedical Books, pp. 163-187. ISBN 9781604564464
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Abstract
RNA interference (RNAi) is a mechanism that inhibits gene expression by causing the degradation of specific RNA molecules or hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (probably as a form of innate immune response), and also plays a role in regulating development and genome maintenance. Small interfering RNA strands (siRNA) are key to the RNAi process, and have complementary nucleotide sequences to the targeted RNA strand. Specific RNAi pathway proteins are guided by the siRNA to the targeted messenger RNA (mRNA), where they 'cleave' the target, breaking it down into smaller portions that can no longer be translated into protein. A type of RNA transcribed from the genome itself, microRNA (miRNA), and works in the same way. This book presents the latest research in the field from around the globe.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Publisher: | Nova Biomedical Books | ||||
| Place of Publication: | New York | ||||
| ISBN: | 9781604564464 | ||||
| Book Title: | RNA interference research progress | ||||
| Editor: | Lyland, Roger T. and Browning, Irving B. | ||||
| Official Date: | 2008 | ||||
| Dates: |
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| Number of Pages: | 323 | ||||
| Page Range: | pp. 163-187 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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