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Epiphenomenon of telomere lengths : lessons from ulcerative colitis
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Arasaradnam, Ramesh P. and Nwokolo, Chuka U. (2012) Epiphenomenon of telomere lengths : lessons from ulcerative colitis. Gut, Vol.61 (No.10). p. 1516. doi:10.1136/gutjnl-2012-302102
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WRAP_Arasaradnam_Letter to the Editor Jan 2012.pdf - Accepted Version Download (536Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/gutjnl-2012-302102
Abstract
We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been shown in senescent somatic cells and also to predispose to cancer. The biological rationale is that telomeres which form a protective cap at the end of chromosomes can be disrupted to undergo double strand breaks, inefficient repair and eventually chromosomal instability. The latter is a well-established precursor to cancer development. Thus, the authors' finding of longer telomeres associated with risk of CRC is particularly intriguing.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Telomere, Ulcerative colitis -- Susceptibility | ||||
Journal or Publication Title: | Gut | ||||
Publisher: | B M J Group | ||||
ISSN: | 0017-5749 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.61 | ||||
Number: | No.10 | ||||
Page Range: | p. 1516 | ||||
DOI: | 10.1136/gutjnl-2012-302102 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Date of first compliant deposit: | 22 December 2015 | ||||
Date of first compliant Open Access: | 22 December 2015 |
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