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Activation mechanisms for organometallic anticancer complexes
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Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2010) Activation mechanisms for organometallic anticancer complexes. In: Jaouen, Gérard and Metzler-Nolte, Nils, (eds.) Medicinal organometallic chemistry. Topics in Organometallic Chemistry, Vol.32 . Berlin ; New York: Springer-Verlag, pp. 21-56. ISBN 9783642131844
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Official URL: http://webcat.warwick.ac.uk/record=b2336810~S1
Abstract
Organometallic complexes offer potential for design as anticancer drugs. They can act as inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which undergo activation by various mechanisms. The activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metal- or ligand-based redox reactions is discussed.
Item Type: | Book Item | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Photochemistry, Organometallic compounds -- Therapeutic use, Antineoplastic agents, Pharmaceutical chemistry, Hydrolysis, Drug activation | ||||
Series Name: | Topics in Organometallic Chemistry | ||||
Journal or Publication Title: | MEDICINAL ORGANOMETALLIC CHEMISTRY | ||||
Publisher: | Springer-Verlag | ||||
Place of Publication: | Berlin ; New York | ||||
ISBN: | 9783642131844 | ||||
ISSN: | 1436-6002 | ||||
Book Title: | Medicinal organometallic chemistry | ||||
Editor: | Jaouen, Gérard and Metzler-Nolte, Nils | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.32 | ||||
Number of Pages: | 291 | ||||
Page Range: | pp. 21-56 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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Data sourced from Thomson Reuters' Web of Knowledge
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