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CD8 controls T cell cross-reactivity
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Wooldridge, L., Laugel, Bruno, Ekeruche, Julia, Clement, Mathew, Berg, Hugo van den, Price, D. A. and Sewell, Andrew K. (2010) CD8 controls T cell cross-reactivity. Journal of Immunology, Volume 185 (Number 8). pp. 4625-4632. doi:10.4049/jimmunol.1001480 ISSN 0022-1767.
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Official URL: http://dx.doi.org/10.4049/jimmunol.1001480
Abstract
Estimates of human alpha beta TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self. The Journal of Immunology, 2010, 185: 4625-4632.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Library of Congress Subject Headings (LCSH): | T cells, Antigens -- Receptors, Ligand binding (Biochemistry), T cells -- Receptors | ||||
| Journal or Publication Title: | Journal of Immunology | ||||
| Publisher: | American Association of Immunologists | ||||
| ISSN: | 0022-1767 | ||||
| Official Date: | 15 October 2010 | ||||
| Dates: |
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| Volume: | Volume 185 | ||||
| Number: | Number 8 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 4625-4632 | ||||
| DOI: | 10.4049/jimmunol.1001480 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Wellcome Trust (London, England), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | BB/H001085/1 (BBSRC) | ||||
| Version or Related Resource: | Conference abstract: Ekeruche, J., et al. (2010). CD8 controls T cell cross-reactivity. In: Special Issue: Annual Congress of the British Society, 6-10 December, Liverpool, UK, Immunology, 131(S1), pp. 172-173. http://wrap.warwick.ac.uk/id/eprint/4562 | ||||
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