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Tryptophan switch for a photoactivated platinum anticancer complex
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Butler, Jennifer S. (Jennifer Suzanne), Woods, Julie A., Farrer, Nicola J., Newton, Mark E. and Sadler, P. J. (2012) Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society, Vol.134 (No.40). pp. 16508-16511. doi:10.1021/ja3074159 ISSN 0002-7863.
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Official URL: http://dx.doi.org/10.1021/ja3074159
Abstract
The octahedral PtIV complex trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1) is potently cytotoxic to cancer cells when irradiated with visible (blue) light. We show that the acute photocytotoxicity can be switched off by low doses (500 μM) of the amino acid l-tryptophan. EPR and NMR spectroscopic experiments using spin traps show that l-Trp quenches the formation of azidyl radicals, probably by acting as an electron donor. l-Trp is well-known as a mediator of electron transfer between distant electron acceptor/donor centers in proteins, and such properties may make the free amino acid clinically useful for controlling the activity of photochemotherapeutic azido PtIV drugs. Since previous work has demonstrated the ability of photoactivated 1 to platinate DNA, this suggests that the high potency of such photoactive platinum complexes is related to their dual attack on cancer cells by radicals and PtII photoproducts.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
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Library of Congress Subject Headings (LCSH): | Tryptophan, Antineoplastic agents, Photochemistry, Platinum -- Therapeutic use | ||||
Journal or Publication Title: | Journal of the American Chemical Society | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 0002-7863 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.134 | ||||
Number: | No.40 | ||||
Page Range: | pp. 16508-16511 | ||||
DOI: | 10.1021/ja3074159 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 23 December 2015 | ||||
Date of first compliant Open Access: | 23 December 2015 | ||||
Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | 247450 (ERC), EP/G006792/1 (EPSRC) |
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