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The effect of high-altitude on human skeletal muscle energetics : 31P-MRS results from the Caudwell Xtreme Everest Expedition
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Earnest, Conrad P., Edwards, Lindsay M., Murray, Andrew J., Tyler, Damian J., Kemp, Graham J., Holloway, Cameron J., Robbins, Peter A., Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E., Grocott, Mike P. and Clarke, Kieran (2010) The effect of high-altitude on human skeletal muscle energetics : 31P-MRS results from the Caudwell Xtreme Everest Expedition. PLoS One, Vol.5 (No.5). e10681. doi:10.1371/journal.pone.0010681 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0010681
Abstract
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using 31P magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and morphology after exposure to hypobaric hypoxia in seven altitude-naïve subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16±1 vs. 22±2 s (mean ± SE, p<0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both groups on their return (PRE: 2.6±0.2 vs. POST: 3.0±0.2 mM, p<0.05). There was significant muscle atrophy post-CXE (PRE: 4.7±0.2 vs. POST: 4.5±0.2 cm2, p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 19 May 2010 | ||||
Dates: |
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Volume: | Vol.5 | ||||
Number: | No.5 | ||||
Page Range: | e10681 | ||||
DOI: | 10.1371/journal.pone.0010681 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | The members of the Caudwell Xtreme Everest Research Group are as follows : Investigators – V. Ahuja, G. Aref-Adib, R. Burnham, A.Chisholm, K. ,Clarke, D. Coates, M. Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, Chris Imray is part of the investigation group |
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