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The cerebral effects of ascent to high altitudes
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Wilson, Mark H, Newman, Stanton and Imray, C. (Chris) (2009) The cerebral effects of ascent to high altitudes. Lancet Neurology, Vol.8 (No.2). pp. 175-191. doi:10.1016/S1474-4422(09)70014-6 ISSN 1474-4422.
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Official URL: http://dx.doi.org/10.1016/S1474-4422(09)70014-6
Abstract
Cellular hypoxia is the common final pathway of brain injury that occurs not just after asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or indirectly (eg, raised intracranial pressure after head injury). We Review recent advances in the understanding of neurological clinical syndromes that occur on exposure to high altitudes, including high altitude headache (HAH), acute mountain sickness (AMS), and high altitude cerebral oedema (HACE), and the genetics, molecular mechanisms, and physiology that underpin them. We also present the vasogenic and cytotoxic bases for HACE and explore venous hypertension as a possible contributory factor. Although the factors that control susceptibility to HACE are poorly understood, the effects of exposure to altitude (and thus hypobaric hypoxia) might provide a reproducible model for the study of cerebral cellular hypoxia in healthy individuals. The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Lancet Neurology | ||||
| Publisher: | Lancet Publishing Group | ||||
| ISSN: | 1474-4422 | ||||
| Official Date: | February 2009 | ||||
| Dates: |
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| Volume: | Vol.8 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 175-191 | ||||
| DOI: | 10.1016/S1474-4422(09)70014-6 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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