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High hopes at high altitudes : pharmacotherapy for acute mountain sickness and high-altitude cerebral and pulmonary oedema
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Wright, A. D., Brearey, S. P. and Imray, C. (Chris) (2008) High hopes at high altitudes : pharmacotherapy for acute mountain sickness and high-altitude cerebral and pulmonary oedema. Expert Opinion on Pharmacotherapy, Vol.9 (No.1). pp. 119-127. doi:10.1517/14656566.9.1.119 ISSN 1465-6566.
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Official URL: http://dx.doi.org/10.1517/14656566.9.1.119
Abstract
The pharmacotherapy of prevention and treatment of acute altitude- related problems – acute mountain sickness, high-altitude cerebral oedema and high-altitude pulmonary oedema – is reviewed. Drug therapy is only part of the answer to the medical problems of high altitude; prevention should include slow ascent and treatment of the more severe illnesses should include appropriate descent. Carbonic anhydrase inhibitors, in particular acetazolamide, remain the most effective drugs in preventing, to a large extent, the symptoms of acute mountain sickness, and can be used in the immediate management of the more severe forms of altitude-related illnesses. Glucocorticoids in relatively large doses are also effective preventative drugs, but at present are largely reserved for the treatment of the more severe acute mountain sickness and acute cerebral oedema. Calcium channel blockers and PDE-5 inhibitors are effective in the management of acute pulmonary oedema. Further work is required to establish the role of antioxidants and anticytokines in these syndromes.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Expert Opinion on Pharmacotherapy | ||||
| Publisher: | Informa Healthcare | ||||
| ISSN: | 1465-6566 | ||||
| Official Date: | January 2008 | ||||
| Dates: |
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| Volume: | Vol.9 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 119-127 | ||||
| DOI: | 10.1517/14656566.9.1.119 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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