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Adipocyte biology in polycystic ovary syndrome
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Barber, T. M. and Franks, S. (2013) Adipocyte biology in polycystic ovary syndrome. Molecular and Cellular Endocrinology, Volume 373 (Number 1-2). pp. 68-76. doi:10.1016/j.mce.2012.10.010 ISSN 0303-7207.
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Official URL: http://dx.doi.org/10.1016/j.mce.2012.10.010
Abstract
Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS and the severity of its phenotypic, biochemical and metabolic features. Evidence to support this link includes data from epidemiological, pathophysiological and genetic studies. Given the importance of obesity in the development and manifestation of PCOS, ongoing research into the many facets of adipocyte biology in women with the condition is important and should continue to be a priority. In this review article, we discuss the existing literature on fat distribution, adipokines, adipocyte hypertrophy and adipocyte steroid metabolism in women with PCOS.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Molecular and Cellular Endocrinology | ||||||
| Publisher: | Elsevier | ||||||
| ISSN: | 0303-7207 | ||||||
| Official Date: | 5 July 2013 | ||||||
| Dates: |
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| Volume: | Volume 373 | ||||||
| Number: | Number 1-2 | ||||||
| Page Range: | pp. 68-76 | ||||||
| DOI: | 10.1016/j.mce.2012.10.010 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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