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Acetazolamide and high altitude diseases
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Bradwell, A., Wright, A., Winterborn, M. and Imray, C. (Chris) (1992) Acetazolamide and high altitude diseases. International Journal of Sports Medicine, Vol.13 (No.1). S63-S64. doi:10.1055/s-2007-1024597
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Official URL: http://dx.doi.org/10.1055/s-2007-1024597
Abstract
Acetazolamide is a useful prophylactic for acute mountain sickness causing marked reduction in headache, nausea, vomiting, weakness, etc. Improvements correlate with increased arterial oxygen concentrations, reduction in proteinuria and peripheral oedema and other objective measures of acute mountain sickness. Evidence that Acetazolamide is beneficial for pulmonary oedema or cerebral oedema is scanty because of the lower frequency of these severe forms of mountain sickness. Dexamethasone, used prophylactically, also reduces the symptoms of acute mountain sickness partly due to its euphoric effect. Use of Acetazolamide as a treatment for established acute mountain sickness has been investigated. Large doses of Acetazolamide increase arterial oxygen levels over a few hours and this leads to a reduction of symptoms but data is limited and faster acting carbonic anhydrides inhibitors such as Methazolamide may be preferable in an emergency situation. There is no comparison of the effectiveness of Acetazolamide with other drugs used for treating acute mountain sickness such as steroids and calcium channel blocking drugs. Also, there is no data on drug combinations which could have additive effects and thereby be more beneficial than individual drugs.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | International Journal of Sports Medicine | ||||
| Publisher: | Georg Thieme Verlag | ||||
| ISSN: | 0172-4622 | ||||
| Official Date: | 1992 | ||||
| Dates: |
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| Volume: | Vol.13 | ||||
| Number: | No.1 | ||||
| Page Range: | S63-S64 | ||||
| DOI: | 10.1055/s-2007-1024597 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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