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Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate
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Imray, C. (Chris), Newbold, K. M., Davis, A., Lavelle-Jones, M. and Neoptolemos, J. P. (1992) Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol.18 (No.4). pp. 373-378. ISSN 0748-7983.
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Official URL: http://www.journals.elsevier.com/ejso-european-jou...
Abstract
The Golden Syrian hamster, which has a bile acid profile similar to that of humans, is often used as an experimental model for cholangiocarcinoma. Unfortunately, most chemical carcinogens result in other tumour types also being induced which can be disadvantageous. In the present study, we describe the development of cholangiocarcinoma associated with precursor lesions of bile duct proliferation and dysplasia which occurred following a single i.v. dose of methylazoxymethyl acetate (10, 20 or 40 mg/kg body weight). Moreover, no other tumours were induced. This model may, therefore, prove useful in investigating the steps involved in the carcinogenesis of cholangiocarcinoma.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | ||||
| Publisher: | W.B. Saunders Co. Ltd. | ||||
| ISSN: | 0748-7983 | ||||
| Official Date: | August 1992 | ||||
| Dates: |
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| Volume: | Vol.18 | ||||
| Number: | No.4 | ||||
| Page Range: | pp. 373-378 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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