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Comparability of hamster with human faecal unconjugated bile acids in a model of colorectal cancer
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Imray, C. (Chris), Minoura, T, Davis, A, Radley, S, Newbold, K M, Lavelle-Jones, M, Lawson, A M, Baker, P R and Neoptolemos, J P (1992) Comparability of hamster with human faecal unconjugated bile acids in a model of colorectal cancer. Anticancer Research, Vol.12 (No.2). pp. 553-558. ISSN 0250-7005.
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Abstract
The relationship between experimental colorectal carcinogenesis and bile acids has usually been investigated in the rat, a species with a markedly different bile acid profile from man. In this study, we show that the hamster faecal bile acid profile is similar to that in man. Rectal cancer was induced in hamsters using twice weekly instillations of N-methyl-N-nitro-N-nitrosoguanidine (MNNG) for 4 weeks at doses of 1-8 mg kg-1. The medcian (range) faecal bile acid concentrations of tumour-bearing hamsters (0.52, 0.46-0.84 mumoles g-1 faeces) was reduced compared to controls (1.08, 0.95-1.65, mumoles g-1) and non-tumour bearing MNNG treated hamsters (1.18, 0.64-1.42 mumoles g-1), largely due to a decrease in cholic acid derivatives (all p less than 0.05) at least). This model may be more suitable for studying the relationship between colorectal cancer and bile acids.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Anticancer Research | ||||
| Publisher: | Int Ins of Anticancer Research | ||||
| ISSN: | 0250-7005 | ||||
| Official Date: | 1992 | ||||
| Dates: |
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| Volume: | Vol.12 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 553-558 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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