Irish Critical Care Trials Group (Including: McAuley, Daniel F., Laffey, John G., O'Kane, Cecilia M., Cross, L. J. Mark, Perkins, Gavin D., Murphy, Lynn, McNally, Christine, Crealey, Grainne and Stevenson, Michael). (2012) Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial. Trials, Vol.13 (No.1). p. 170. doi:10.1186/1745-6215-13-170 ISSN 1745-6215.

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Abstract

Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure. There are in vitro, animal studies and pre-clinical data suggesting that statins may be beneficial in ALI. The Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial is a multicenter, prospective, randomized, allocation concealed, double-blind, placebo-controlled clinical trial which aims to test the hypothesis that treatment with simvastatin will improve clinical outcomes in patients with ALI.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Lungs -- Wounds and injuries -- Treatment, Statins (Cardiovascular agents)
Journal or Publication Title:	Trials
Publisher:	Biomed Central
ISSN:	1745-6215
Official Date:	2012
Dates:	Date Event 2012 Published
Volume:	Vol.13
Number:	No.1
Page Range:	p. 170
DOI:	10.1186/1745-6215-13-170
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Funder:	Medical Research Council (Great Britain) (MRC), National Institute for Health Research (Great Britain) (NIHR), Scotland. Chief Scientist Office, National Institute for Social Care and Health Research (Wales) (NISCHR), Northern Ireland. Public Health Agency. HSC Research & Development Division, Ireland. Health Research Board, Intensive Care Society of Ireland
Grant number:	HRA_POR/2010/131 (HRB)

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