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Exoproteomics : exploring the world around biological systems
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Armengaud, Jean, Christie-Oleza, Joseph Alexander, Clair, Gérémy, Malard, Véronique and Duport, Catherine (2012) Exoproteomics : exploring the world around biological systems. Expert Review of Proteomics, Vol.9 (No.5). pp. 561-575. doi:10.1586/epr.12.52 ISSN 1478-9450.
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Official URL: http://dx.doi.org/10.1586/EPR.12.52
Abstract
The term 'exoproteome' describes the protein content that can be found in the extracellular proximity of a given biological system. These proteins arise from cellular secretion, other protein export mechanisms or cell lysis, but only the most stable proteins in this environment will remain in abundance. It has been shown that these proteins reflect the physiological state of the cells in a given condition and are indicators of how living systems interact with their environments. High-throughput proteomic approaches based on a shotgun strategy, and high-resolution mass spectrometers, have modified the authors' view of exoproteomes. In the present review, the authors describe how these new approaches should be exploited to obtain the maximum useful information from a sample, whatever its origin. The methodologies used for studying secretion from model cell lines derived from eukaryotic, multicellular organisms, virulence determinants of pathogens and environmental bacteria and their relationships with their habitats are illustrated with several examples. The implication of such data, in terms of proteogenomics and the discovery of novel protein functions, is discussed.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Expert Review of Proteomics | ||||
Publisher: | Expert Reviews Ltd. | ||||
ISSN: | 1478-9450 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.9 | ||||
Number: | No.5 | ||||
Page Range: | pp. 561-575 | ||||
DOI: | 10.1586/epr.12.52 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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