The Library
Chondrocalcinosis is common in the absence of knee involvement
Tools
Abhishek, Abhishek, Doherty, Sally A., Maciewicz, Rose A., Muir, Kenneth, Zhang, Weiya and Doherty, Michael (2012) Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research & Therapy, Volume 14 (Number 5). Article no. R205. doi:10.1186/ar4043 ISSN 1478-6354.
|
Text
WRAP_Muir_ar4043 (1).pdf - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. Download (406Kb) | Preview |
Official URL: http://dx.doi.org/10.1186/ar4043
Abstract
Introduction:
We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement.
Methods:
This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL). All participants (n = 3,170) had radiographs of the knees, hands, and pelvis. These were scored for radiographic changes of osteoarthritis (OA), for CC at knees, hips, symphysis pubis, and wrists, and for MCPJ calcification. The prevalence of MCPJ calcification and CC overall, at each joint, and in the presence or absence of knee involvement, was calculated.
Results:
The knee was the commonest site of CC, followed by wrists, hips, and symphysis pubis. CC was more likely to be bilateral at knees and wrists but unilateral at hips. MCPJ calcification was usually bilateral, and less common than CC at knees, hips, wrists, and symphysis pubis. Unlike that previously reported, CC commonly occurred without any knee involvement; 44.4% of wrist CC, 45.9% of hip CC, 45.5% of symphysis pubis CC, and 31.3% of MCPJ calcification occurred in patients without knee CC. Those with meniscal or hyaline articular cartilage CC had comparable ages (P = 0.21), and neither preferentially associated with fibrocartilage CC at distant joints.
Conclusions:
CC visualized on a plain radiograph commonly occurs at other joints in the absence of radiographic knee CC. Therefore, knee radiographs alone are an insufficient screening test for CC. This has significant implications for clinical practice, for epidemiologic and genetic studies of CC, and for the definition of OA patients with coexistent crystal deposition.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Chondrocalcinosis, Arthritis -- Research, Knee | ||||
Journal or Publication Title: | Arthritis Research & Therapy | ||||
Publisher: | BioMed Central Ltd. | ||||
ISSN: | 1478-6354 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
Volume: | Volume 14 | ||||
Number: | Number 5 | ||||
Page Range: | Article no. R205 | ||||
DOI: | 10.1186/ar4043 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year