The Library
Paracetamol-loaded poly(ε-caprolactone) layered silicate nanocomposites prepared using hot-melt extrusion
Tools
Campbell, Kayleen, Qi, Sheng, Craig, Duncan Q.M. and McNally, Tony (2009) Paracetamol-loaded poly(ε-caprolactone) layered silicate nanocomposites prepared using hot-melt extrusion. Journal of Pharmaceutical Sciences, Vol.98 (No.12). pp. 4831-4843. doi:10.1002/jps.21787 ISSN 0022-3549.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/jps.21787
Abstract
Composites of paracetamol loaded poly(ε-caprolactone) with layered silicates (nanoclays) were prepared using hot-melt extrusion. The paracetamol crystals and layered silicates formed both intercalated and partially exfoliated nanocomposite morphologies depending on composition. The dissolution and initial burst effect were retarded slightly by the nanoclay. Tm and Tc of poly(caprolactone) (PCL) were unaffected by the presence of nanoclay, but the crystalline content decreased. The highly dispersed nanoplatelets hindered the mobility of PCL chains and alter the crystallization behavior of PCL. The Tg of PCL increased by up to 15°C on addition of a synthetic fluromica, as the nanoclay constrained chain motion and tethered PCL chains through hydrogen bonding to hydroxyl groups on the edges of the clay platelets. The tensile mechanical properties of PCL were unaffected when a naturally derived clay (montmorillonite) and paracetamol were blended. In contrast, the modulus of PCL increased by 500% and the stress and elongation at break decreased by 30% for composites prepared with a partially synthetic fluoromica. The study has therefore demonstrated that nanocomposite formation is a potentially highly useful means of manipulating the mechanical properties of melt extrusion systems.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | Journal of Pharmaceutical Sciences | ||||
Publisher: | John Wiley & Sons, Inc. | ||||
ISSN: | 0022-3549 | ||||
Official Date: | December 2009 | ||||
Dates: |
|
||||
Volume: | Vol.98 | ||||
Number: | No.12 | ||||
Page Range: | pp. 4831-4843 | ||||
DOI: | 10.1002/jps.21787 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |