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Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides
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Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
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Official URL: http://dx.doi.org/10.1016/j.jinorgbio.2010.04.009
Abstract
We show that UVA irradiation (365 nm) of the Pt-IV complex trans,trans,trans-[(PtCl2)-Cl-IV(OH)(2)(dimethylamine) (isopropylamine)] (1), induces reduction to Pt-II photoproducts. For the mixed amine Pt-II complex, trans[(PtCl2)-Cl-II(isopropylamine)(methylamine)] (2), irradiation at 365 nm increases the rate and extent of hydrolysis, triggering the formation of diaqua species. Additionally, irradiation increases the extent of reaction of complex 2 with guanosine-5'-monophosphate and affords mainly the bis-adduct, while reactions with adenosine-5'-monophosphate and cytidine-5'-monophosphate give rise only to mono-nucleotide adducts. Density Functional Theory calculations have been used to obtain insights into the electronic structure of complexes 1 and 2, and their photophysical and photochemical properties. UVA-irradiation can contribute to enhanced cytotoxic effects of diamine platinum drugs with trans geometry.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Irradiation, Platinum compounds, Antineoplastic agents, Photochemistry | ||||
Journal or Publication Title: | Journal of Inorganic Biochemistry | ||||
Publisher: | Elsevier Science Inc | ||||
ISSN: | 0162-0134 | ||||
Official Date: | September 2010 | ||||
Dates: |
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Volume: | Vol.104 | ||||
Number: | No.9 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 909-918 | ||||
DOI: | 10.1016/j.jinorgbio.2010.04.009 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 3 December 2015 | ||||
Date of first compliant Open Access: | 3 December 2015 | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Spain. Ministerio de Educación y Ciencia (MEC), Medical Research Council (Great Britain) (MRC), Universidad Autónoma de Madrid (UAM), Seventh Framework Programme (European Commission) (FP7) | ||||
Grant number: | SAF2006-03296 (MEC), SAF2009-09431 (MEC), G0701062 (MRC), G006792 (EPSRC), 220281 PHOTORUACD (FP7) |
Data sourced from Thomson Reuters' Web of Knowledge
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