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Self-reported knee and foot alignments in early adult life and risk of osteoarthritis
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McWilliams, Daniel F., Doherty, Sally A., Maciewicz, Rose A., Muir, Kenneth, Zhang, Weiya and Doherty, Michael (2010) Self-reported knee and foot alignments in early adult life and risk of osteoarthritis. Arthritis Care & Research, Vol.62 (No.4). pp. 489-495. doi:10.1002/acr.20169 ISSN 2151-464X.
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Official URL: http://dx.doi.org/10.1002/acr.20169
Abstract
Objective. To determine whether self-reported early adult life malalignment of knees or feet are risk factors for knee or hip osteoarthritis (OA).
Methods. Participants in the Genetics of Osteoarthritis and Lifestyle case-control database were sent a questionnaire (n = 3,022) containing line-drawing instruments for self-reported knee and foot alignment at ages 20-29 years. Respondents were categorized as having straight, valgus, or varus knee, and straight, toe-in, or toe-out feet. Radiographic criteria were used to define current isolated knee or hip OA, combined knee and hip OA, or non-OA controls. Odds ratios (ORs), adjusted ORs, and 95% confidence intervals (95% CIs) were calculated and logistic regression was performed.
Results. The response rate was 72%; 87.5% of responders (n = 1,901) completed the alignment questions. Increased risk of isolated knee OA occurred with early adult varus (adjusted OR 5.16, 95% CI 2.87-9.41) and valgus knees (adjusted OR 3.16, 95% CI 1.04-9.64). The positive association between knee OA and toe-in foot was explained by varus knee. There was an increased risk of combined knee/hip OA from varus (adjusted OR 4.52, 95% CI 2.39-8.53) and valgus knees (adjusted OR 3.07, 95% CI 0.99-9.54). Varus knee was associated with risk of medial tibiofemoral OA, whereas valgus knee was associated with risk of lateral tibiofemoral and lateral patellofemoral OA. Toe-out foot was associated with reduced medial patellofemoral OA. For knee OA, a multiplicative interaction analysis between occupational risks and varus/valgus yielded an ORint of 3.20 (95% CI 1.08-9.49).
Conclusion. Constitutional alignment of the leg in terms of varus or valgus knee or foot rotation may be a significant factor in determining development and distribution of knee but not hip OA.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Arthritis Care & Research | ||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
| ISSN: | 2151-464X | ||||
| Official Date: | April 2010 | ||||
| Dates: |
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| Volume: | Vol.62 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 489-495 | ||||
| DOI: | 10.1002/acr.20169 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | AstraZeneca, Macclesfield, UK, Arthritis Research Campaign (ICAC) | ||||
| Grant number: | 14851 |
Data sourced from Thomson Reuters' Web of Knowledge
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