The Library
The pharmacokinetics of enoxacin in elderly patients
Tools
Wise, R., Baker, S. L., Misra, M. and Griggs, Deborah (1987) The pharmacokinetics of enoxacin in elderly patients. Journal of Antimicrobial Chemotherapy, Vol.19 (No.3). pp. 343-350. doi:10.1093/jac/19.3.343 ISSN 0305-7453.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1093/jac/19.3.343
Abstract
Twenty-three patients of greater than 70 years of age, with proven urinary tract infections were treated with 200 mg of enoxacin twice daily. Serial blood samples were taken on day 1 and peak and trough levels on days 3 and 5. Enoxacin and oxo-enoxacin plasma levels were measured. The mean plasma half-lives of enoxacin and the oxo-metabolite were 6.1 h and 6.7 h respectively. The 2 h plasma level of enoxacin increased from a mean of 1.5 mg/1 on day 1 to 2.65 mg/1 on day 3 and 2.80 mg/1 on day 5. No significant accumulation of the oxo-metabolite (as judged by the 2 h level) occurred. No alteration in enoxacin dosing in the elderly compared with that in younger patients is suggested. Eighty-five per cent of the patients were cured of their infection and no significant adverse advents were noted.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Journal of Antimicrobial Chemotherapy | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0305-7453 | ||||
Official Date: | 1987 | ||||
Dates: |
|
||||
Volume: | Vol.19 | ||||
Number: | No.3 | ||||
Page Range: | pp. 343-350 | ||||
DOI: | 10.1093/jac/19.3.343 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |