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Does endotoxaemia contribute to osteoarthritis in obese patients?
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Metcalfe, David, Harte, Alison L., Aletrari, Mina Olga, Al Daghri, Nasser M., Al Disi, Dara, Tripathi, Gyanendra and McTernan, P. G. (2012) Does endotoxaemia contribute to osteoarthritis in obese patients? Clinical science, Volulme 123 (Number 11). pp. 627-34. doi:10.1042/CS20120073 ISSN 1470-8736.
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Official URL: http://dx.doi.org/10.1042/CS20120073
Abstract
OA (osteoarthritis) is a degenerative condition associated with obesity. A number of metabolic explanations have been proposed to explain the association between obesity and OA in non-weight-bearing joints; however, none of these hypotheses have been demonstrated empirically. In the present Hypothesis article, we recognize that obesity is associated with compromised gut mucosa, translocation of microbiota and raised serum LPS (lipopolysaccharide). The consequent activation of the innate immune response leads to increased serum titres of inflammatory mediators in obese patients, with both local and systemic markers of inflammation associated with onset and progression of OA. Furthermore, a number of workers have shown that articular cartilage repair is impaired by a range of inflammatory mediators, both in vitro and in vivo. We propose that metabolic endotoxaemia, caused by impaired gastric mucosa and low-grade chronic inflammation, may contribute to the onset and progression of OA in obese patients. This may account for the association between obesity and OA at non-weight-bearing joints which cannot be explained by biomechanical factors.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Clinical science | ||||
| Publisher: | Portland Press Ltd. | ||||
| ISSN: | 1470-8736 | ||||
| Official Date: | December 2012 | ||||
| Dates: |
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| Volume: | Volulme 123 | ||||
| Number: | Number 11 | ||||
| Page Range: | pp. 627-34 | ||||
| DOI: | 10.1042/CS20120073 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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