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A detailed study on understanding glycopolymer library and Con A interactions
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Gou, Yanzi, Geng, Jin, Richards, Sarah-Jane, Burns, James A., Becer, C. Remzi and Haddleton, David M. (2013) A detailed study on understanding glycopolymer library and Con A interactions. Journal of Polymer Science Part A: Polymer Chemistry, Volume 51 (Number 12). pp. 2588-2597. doi:10.1002/pola.26646 ISSN 0887-624X.
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Official URL: http://dx.doi.org/10.1002/pola.26646
Abstract
Synthetic glycopolymers are important natural oligosaccharides mimics for many biological applications. To develop glycopolymeric drugs and therapeutic agents, factors that control the receptor-ligand interaction need to be investigated. A library of well-defined glycopolymers has been prepared by the combination of copper mediated living radical polymerization and CuAAC click reaction via post-functionalization of alkyne-containing precursor polymers with different sugar azides. Employing Concanavalin A as the model receptor, we explored the influence of the nature and densities of different sugars residues (mannose, galactose, and glucose) on the stoichiometry of the cluster, the rate of the cluster formation, the inhibitory potency of the glycopolymers, and the stability of the turbidity through quantitative precipitation assays, turbidimetry assays, inhibitory potency assays, and reversal aggregation assays. The diversities of binding properties contributed by different clustering parameters will make it possible to define the structures of the multivalent ligands and densities of binding epitopes tailor-made for specific functions in the lectin-ligand interaction. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 2588–2597
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymerization , Chemical reactions, Biomedical materials, Biosynthesis, Biochemistry, Ligand binding (Biochemistry) | ||||
Journal or Publication Title: | Journal of Polymer Science Part A: Polymer Chemistry | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 0887-624X | ||||
Official Date: | 15 June 2013 | ||||
Dates: |
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Volume: | Volume 51 | ||||
Number: | Number 12 | ||||
Page Range: | pp. 2588-2597 | ||||
DOI: | 10.1002/pola.26646 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain). Dorothy Hodgkin Fellowship (RSDHF), China Scholarship Council (CSC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF) |
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