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Photoactivatable metal complexes : from theory to applications in biotechnology and medicine
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Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
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WRAP_Sadler_Photoactivatable_metal_Phil. Trans. R. Soc. A-2013-Smith-.pdf - Published Version Available under License Creative Commons Attribution. Download (708Kb) | Preview |
Official URL: http://dx.doi.org/10.1098/rsta.2012.0519
Abstract
This short review highlights some of the exciting new experimental and theoretical developments in the field of photoactivatable metal complexes and their applications in biotechnology and medicine. The examples chosen are based on some of the presentations at the Royal Society Discussion Meeting in June 2012, many of which are featured in more detail in other articles in this issue. This is a young field. Even the photochemistry of well-known systems such as metal–carbonyl complexes is still being elucidated. Striking are the recent developments in theory and computation (e.g. time-dependent density functional theory) and in ultrafast-pulsed radiation techniques which allow photochemical reactions to be followed and their mechanisms to be revealed on picosecond/nanosecond time scales. Not only do some metal complexes (e.g. those of Ru and Ir) possess favourable emission properties which allow functional imaging of cells and tissues (e.g. DNA interactions), but metal complexes can also provide spatially controlled photorelease of bioactive small molecules (e.g. CO and NO)—a novel strategy for site-directed therapy. This extends to cancer therapy, where metal-based precursors offer the prospect of generating excited-state drugs with new mechanisms of action that complement and augment those of current organic photosensitizers.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Biotechnology, Photochemistry, Photochemistry -- Research, Metal complexes, Complex compounds, Cancer -- Treatment | ||||
Journal or Publication Title: | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | ||||
Publisher: | The Royal Society Publishing | ||||
ISSN: | 1364-503X | ||||
Official Date: | 28 July 2013 | ||||
Dates: |
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Volume: | Volume 371 | ||||
Number: | Number 1995 | ||||
Page Range: | p. 20120519 | ||||
DOI: | 10.1098/rsta.2012.0519 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 24 December 2015 | ||||
Date of first compliant Open Access: | 24 December 2015 | ||||
Funder: | European Research Council (ERC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | 247450 (ERC) |
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