The Library
Characterisation of pharmaceutical and polymer formulations by novel mass spectrometry approaches
Tools
Snelling, Jonathon R. (2012) Characterisation of pharmaceutical and polymer formulations by novel mass spectrometry approaches. PhD thesis, University of Warwick.
|
Text
WRAP_THESIS_Snelling_2012.pdf - Submitted Version Download (7Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b2661495~S1
Abstract
Since its inception at the beginning of the twentieth century, the field of mass
spectrometry has progressed from the realm of physics to an analytical tool that can
be found in many fields of science. This is in large part due to continued
development and innovation in instrument design.
This thesis explores two significant areas of development in mass spectrometry in
the last ten years. The first is the development of ambient ionisation techniques.
These techniques require little or no sample preparation, and as a result can provide a
rapid means of direct analysis. The second development is the commercialisation of
ion mobility – mass spectrometry (IM-MS). This technique enables information on
the shape of the analyte of interest to be obtained in addition to its mass-to-charge
ratio. The technique has the potential to simplify the spectra acquired from complex
mixtures and to separate out isobaric species that cannot be resolved by mass
spectrometry alone.
Both of these developments have been applied to two important areas of analytical
science – the characterisation of pharmaceutical commercial products and synthetic
polymer formulations.
A modification of the extractive electrospray ionisation (EESI) technique has been
developed and has been termed thermally assisted – EESI (TA-EESI). TA-EESI and
the atmospheric pressure solids analysis probe (ASAP) have been coupled with IMMS.
IM-MS has been used as a rapid separation technique to resolve isomeric species
within complex polysorbate formulations. Recently introduced novel polymer
architectures synthesised by simple methods have been studied using IM-MS
experiments.
Item Type: | Thesis (PhD) | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
||||
Library of Congress Subject Headings (LCSH): | Mass spectrometry, Electrospray ionization mass spectrometry, Ion mobility spectroscopy, Drugs -- Analysis | ||||
Official Date: | August 2012 | ||||
Dates: |
|
||||
Institution: | University of Warwick | ||||
Theses Department: | School of Life Sciences | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Scrivens, James H.; Hilton, Gillian R. | ||||
Extent: | xviii, 206 leaves : illustrations, charts. | ||||
Language: | eng |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year