Brookes, Michael H. (1985) The synthesis of the enantiomers of lipoic acid. PhD thesis, University of Warwick.

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Abstract

Lipoic acid is a biologically important molecule.
Whilst the racemate has been available by a number of
syntheses for many years, no convenient preparation of the
pure enantiomers has so far been described. All the
evidence so far presented indicates that only the
dextrorotatory isomer is active in vivo, the absolute
configuration of which has not been established with
certainty. To further elucidate the biochemical role(s)
and biosynthesis of this compound, a convenient EPC
synthesis would be beneficial. This thesis describes
the development of a route to the (R)- and (S)- forms
of the target molecule from a member of the "chiral pool".
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Item Type:	Thesis (PhD)
Subjects:	Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH):	Lipoic acid, Enantiomers, Biosynthesis
Official Date:	February 1985
Dates:	Date Event February 1985 Submitted
Institution:	University of Warwick
Theses Department:	Department of Chemistry
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Golding, Bernard T., Hudson, A. T.
Sponsors:	Science and Engineering Research Council (Great Britain) (SERC) ; Wellcome Trust (London, England)
Extent:	vii, 226 leaves
Language:	eng

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